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Numb (phospho-Ser276) rabbit pAb
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ES14425
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Numb (phospho-Ser276) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Protein numb homolog (h-Numb) (Protein S171)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human Numb (Ser276)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 70kD
GeneID: 8650
Human Swiss-Prot No: P49757
Cellular localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],