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OTOG rabbit pAb
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ES14357
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50 µL $148.00
100 µL $248.00
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Overview

Product name: OTOG rabbit pAb
Reactivity: Human; Mouse
Source: Rabbit
Dilutions: IHC-p 1：50-200
Immunogen: Synthesized peptide derived from human OTOG AA range: 2706-2756
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 322kD
GeneID: 340990
Human Swiss-Prot No: Q6ZRI0
Cellular localization: Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular space . Found in fiber-like structures during the maturation process of the tectorial membrane. .
Background: The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014],