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PEN2 rabbit pAb
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ES14162
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PEN2 rabbit pAb
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilutions: IHC-p 1：50-200
Immunogen: Synthesized peptide derived from human PEN2 AA range: 51-101
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 11kD
GeneID: 55851
Human Swiss-Prot No: Q9NZ42
Cellular localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. .
Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],