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Stat6 (phospho Tyr641) rabbit pAb
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ES1409
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Stat6 (phospho Tyr641) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Tyr641. AA range:608-657
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 94kD
GeneID: 6778
Human Swiss-Prot No: P42226
Cellular localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],