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PLCγ2 (phospho-Tyr759) rabbit pAb
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ES14068
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PLCγ2 (phospho-Tyr759) rabbit pAb
Reactivity: Human;Mouse
Alternative Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Source: Rabbit
Dilutions: WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
Immunogen: Synthesized phosho peptide around human PLCγ2 (Tyr759)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 148kD
GeneID: 5336
Human Swiss-Prot No: P16885
Cellular localization: intracellular,cytosol,plasma membrane,extracellular exosome,
Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],