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RBP2 rabbit pAb
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ES13442
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50 µL $148.00
100 µL $248.00
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Overview

Product name: RBP2 rabbit pAb
Reactivity: Human; Mouse
Source: Rabbit
Dilutions: IHC-p 1：50-200
Immunogen: Synthesized peptide derived from human RBP2 AA range: 108-158
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 355kD
GeneID: 5903
Human Swiss-Prot No: P49792
Cellular localization: Nucleus . Nucleus membrane . Nucleus, nuclear pore complex . Nucleus envelope . Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481). .
Background: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008],