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HDAC8 (phospho Ser39) rabbit pAb
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ES1325
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Overview

Product name: HDAC8 (phospho Ser39) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human HDAC8 around the phosphorylation site of Ser39. AA range:5-54
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 42kD
GeneID: 55869
Human Swiss-Prot No: Q9BY41
Cellular localization: Nucleus . Chromosome . Cytoplasm . Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). .
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],