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SNAPN rabbit pAb
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ES13039
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50 µL $148.00
100 µL $248.00
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Overview

Product name: SNAPN rabbit pAb
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human SNAPN AA range: 9-59
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 15kD
GeneID: 23557
Human Swiss-Prot No: O95295
Cellular localization: Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Golgi apparatus membrane . Lysosome membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. .
Background: The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],