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SNX13 rabbit pAb
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ES13032
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Overview

Product name: SNX13 rabbit pAb
Reactivity: Human; Mouse
Alternative Names: Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)
Source: Rabbit
Dilutions: WB 1:500-2000
Immunogen: Synthesized peptide derived from human SNX13 AA range: 602-652
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 105kD
GeneID: 23161
Human Swiss-Prot No: Q9Y5W8
Cellular localization: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Background: This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],