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UN13B rabbit pAb
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ES12423
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50 µL $148.00
100 µL $248.00
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Overview

Product name: UN13B rabbit pAb
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human UN13B AA range: 1325-1375
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 175kD
GeneID: 10497
Human Swiss-Prot No: O14795
Cellular localization: Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008],