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KLOT rabbit pAb
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ES11915
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50 µL $148.00
100 µL $248.00
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Overview

Product name: KLOT rabbit pAb
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilutions: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from part region of human protein AA range: 400-500
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 111kD
GeneID: 9365
Human Swiss-Prot No: Q9UEF7
Cellular localization: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Apical cell membrane ; Single-pass type I membrane protein . Isoform 1 shedding leads to a soluble peptide. .; [Isoform 2]: Secreted .; [Klotho peptide]: Secreted .
Background: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008],