| Product name: |
IDE/Insulin Degrading Enzyme Mouse mAb |
| Reactivity: |
Human |
| Alternative Names: |
Abeta degrading protease, insulin degrading enzyme, Insulin protease, Insulinase, INSULYSIN |
| Source: |
Mouse |
| Dilutions: |
WB 1:1,000 IHC 1:200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
118kDa |
| GeneID: |
3416 |
| Human Swiss-Prot No: |
P14735 |
| Cellular localization: |
Cell membrane, Cytoplasm, Membrane, Secreted |
| Background: |
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. |
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