| Product name: |
FH/Fumarase Mouse mAb |
| Reactivity: |
Human, Rat, Mouse |
| Alternative Names: |
Fumarase, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1 |
| Source: |
Mouse |
| Dilutions: |
WB 1:3,000 IF 1:100-200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
50kDa |
| GeneID: |
2271 |
| Human Swiss-Prot No: |
P07954 |
| Cellular localization: |
Cytoplasm and Mitochondrion. |
| Background: |
Fumarase (FH) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Tricarboxylic Acid Cycle [TCA] or the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the absence of the signal sequence found in the mitochondrial variety. |
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