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CK16 Mouse mAb
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EM1056
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CK16 Mouse mAb
Reactivity: Human, Rat, Mouse
Alternative Names: Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK
Source: Mouse
Dilutions: IHC 1:200
Immunogen: Synthetic Peptide
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed Band: 51kDa
GeneID: 3868
Human Swiss-Prot No: P08779
Cellular localization: Intermediate filament
Background: Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.