Product name: |
CK16 Mouse mAb |
Reactivity: |
Human, Rat, Mouse |
Alternative Names: |
Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
Source: |
Mouse |
Dilutions: |
IHC 1:200 |
Immunogen: |
Synthetic Peptide |
Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
Clonality: |
Monoclonal |
Isotype: |
IgG1 |
Concentration: |
1mg/mL |
Observed Band: |
51kDa |
GeneID: |
3868 |
Human Swiss-Prot No: |
P08779 |
Cellular localization: |
Intermediate filament |
Background: |
Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. |