| Product name: |
phospho-MLKL (S358) (6B4) Mouse mAb |
| Reactivity: |
Human |
| Alternative Names: |
Mixed lineage kinase domain like protein, FLJ34389 |
| Source: |
Mouse |
| Dilutions: |
IHC 1:100-200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
54kDa |
| GeneID: |
197259 |
| Human Swiss-Prot No: |
Q8NB16 |
| Cellular localization: |
Cell membrane, Cytoplasm, Membrane |
| Background: |
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358. |
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