| Product name: |
Smad3 (4C9) Mouse mAb |
| Reactivity: |
Human, Rat, Mouse |
| Alternative Names: |
hMAD3 antibody, HSPC193 antibody, LDS1C antibody, MADH3 antibody, JV15 2 antibody |
| Source: |
Mouse |
| Dilutions: |
WB 1:1,000-2,000 IHC 1:100-200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
52kDa |
| GeneID: |
4088 |
| Human Swiss-Prot No: |
P84022 |
| Cellular localization: |
Cytoplasm, Nucleus |
| Background: |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. |
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