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CD68 Mouse mAb
EM1050
Specification: Price:
50 µl $148.00
100 µl $248.00

Overview

Product name: CD68 Mouse mAb
Species reactivity: Human, Rat, Mouse
Reactivity: Human, Rat, Mouse
Alternative Names: CD68 molecule, GP110, Macrosialin, SCARD1
Source: Mouse
Applications : IHC
Species: Human
Recommended dilutions: IHC 1:200
Immunogen: Synthetic Peptide
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/ml
Observed band: 37kDa
GeneID(Human): 968
Human Swiss-Prot No.: P34810
Cellular localization: Cell membrane and Endosome membrane. Lysosome membrane
Background: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.

Precision

Intra-assay Precision (Precision within an assay):CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Inter-assay Precision (Precision between assays):CV%<10%

Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.