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Claudin-2 (8H11) Mouse mAb

Catalog No. : EM1403

Specification Price
50µl $148
100µl $248

Overview

Product name: Claudin-2 (8H11) Mouse mAb
Source: Mouse
Applications: WB, IHC
Species reactivity: Human,Rat,Mouse
Recommended dilutions: WB 1:1,000-2,000   IHC:1;100-1:200
Immunogen: Synthetic Peptide
Specificity: Human
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/ml
Observed band: 25kDa
GeneID(Human): 9075
Human Swiss-Prot No.: P57739
Cellular localization: Cell junction,tight junction,Cell membrane
Alternative Names: N/A
Background: The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
  • Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 (EM1403)Mouse mAb diluted at 1:2000.

  • Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 (EM1403)Mouse mAb diluted at 1:200.

  • Immunohistochemical analysis of paraffin-embedded Human Endometrial Carcinoma Tissue using Claudin-2 (EM1403)Mouse mAb diluted at 1:200.